Klotho prevents epithelial–mesenchymal transition through Egr-1 downregulation in diabetic kidney disease

INTRODUCTION: As a key event leading to tubulointerstitial fibrosis in diabetic kidney disease (DKD), epithelial–mesenchymal transition (EMT) has drawn increasing attention from researchers. The antiaging protein Klotho attenuates renal fibrosis in part by inhibiting ERK1/2 signaling in DKD. Early g...

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Detaylı Bibliyografya
Yayımlandı:BMJ Open Diabetes Res Care
Asıl Yazarlar: Li, Yang, Xue, Meng, Hu, Fang, Jia, Yijie, Zheng, Zongji, Yang, Yanlin, Liu, Xiaolian, Yang, Yuelian, Wang, Yanjing
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BMJ Publishing Group 2021
Konular:
Pathophysiology/Complications
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8186752/
https://ncbi.nlm.nih.gov/pubmed/34099438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bmjdrc-2020-002038
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