Temporal evolution of cellular heterogeneity during the progression to advanced AR-negative prostate cancer

Despite advances in the development of highly effective androgen receptor (AR)-directed therapies for the treatment of men with advanced prostate cancer, acquired resistance to such therapies frequently ensues. A significant subset of patients with resistant disease develop AR-negative tumors that l...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Brady, Nicholas J., Bagadion, Alyssa M., Singh, Richa, Conteduca, Vincenza, Van Emmenis, Lucie, Arceci, Elisa, Pakula, Hubert, Carelli, Ryan, Khani, Francesca, Bakht, Martin, Sigouros, Michael, Bareja, Rohan, Sboner, Andrea, Elemento, Olivier, Tagawa, Scott, Nanus, David M., Loda, Massimo, Beltran, Himisha, Robinson, Brian, Rickman, David S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8185096/
https://ncbi.nlm.nih.gov/pubmed/34099734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23780-y
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