Generation of functional liver organoids on combining hepatocytes and cholangiocytes with hepatobiliary connections ex vivo

In the liver, the bile canaliculi of hepatocytes are connected to intrahepatic bile ducts lined with cholangiocytes, which remove cytotoxic bile from the liver tissue. Although liver organoids have been reported, it is not clear whether the functional connection between hepatocytes and cholangiocyte...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Tanimizu, Naoki, Ichinohe, Norihisa, Sasaki, Yasushi, Itoh, Tohru, Sudo, Ryo, Yamaguchi, Tomoko, Katsuda, Takeshi, Ninomiya, Takafumi, Tokino, Takashi, Ochiya, Takahiro, Miyajima, Atsushi, Mitaka, Toshihiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8185093/
https://ncbi.nlm.nih.gov/pubmed/34099675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23575-1
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