Deubiquitinating enzyme OTUB1 promotes cancer cell immunosuppression via preventing ER-associated degradation of immune checkpoint protein PD-L1

Upregulation of programmed death ligand 1 (PD-L1) helps tumor cells escape from immune surveillance, and therapeutic antibodies targeting PD-1/PD-L1 have shown better patient outcomes only in several types of malignancies. Recent studies suggest that the clinical efficacy of anti-PD-1/PD-L1 treatmen...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Zhu, Dan, Xu, Ruidan, Huang, Xinping, Tang, Zefang, Tian, Yonglu, Zhang, Jinfang, Zheng, Xiaofeng
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8184985/
https://ncbi.nlm.nih.gov/pubmed/33328570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-020-00700-z
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