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E2 ubiquitin conjugating enzymes regulate the deubiquitinating activity of OTUB1
OTUB1 is a Lys48-specific deubiquitinating enzyme that forms a complex in vivo with E2 ubiquitin conjugating enzymes including UBC13 and UBCH5. OTUB1 binds to E2~Ub thioester intermediates and prevent ubiquitin transfer, thereby non-catalytically inhibiting accumulation of polyubiquitin. We report h...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2013
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3941643/ https://ncbi.nlm.nih.gov/pubmed/23955022 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2655 |
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