E2 ubiquitin conjugating enzymes regulate the deubiquitinating activity of OTUB1

OTUB1 is a Lys48-specific deubiquitinating enzyme that forms a complex in vivo with E2 ubiquitin conjugating enzymes including UBC13 and UBCH5. OTUB1 binds to E2~Ub thioester intermediates and prevent ubiquitin transfer, thereby non-catalytically inhibiting accumulation of polyubiquitin. We report h...

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Bibliografiske detaljer
Main Authors: Wiener, Reuven, DiBello, Anthony T., Lombardi, Patrick, Guzzo, Catherine M., Zhang, Xiangbin, Matunis, Michael J., Wolberger, Cynthia
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3941643/
https://ncbi.nlm.nih.gov/pubmed/23955022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2655
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