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The mechanism of OTUB1 inhibition of ubiquitination
Histones are ubiquitinated in response to DNA double strand breaks (DSB), promoting recruitment of repair proteins to chromatin(1). UBC13 (UBE2N) is an ubiquitin conjugating enzyme (E2) that heterodimerizes with UEV1a(2) and synthesizes K63–linked polyubiquitin (K63Ub) chains at DSB sites in concert...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3319311/ https://ncbi.nlm.nih.gov/pubmed/22367539 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10911 |
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