OTUB1 non-catalytically stabilizes the E2 ubiquitin-conjugating enzyme UBE2E1 by preventing its autoubiquitination

OTUB1 is a deubiquitinating enzyme that cleaves Lys-48–linked polyubiquitin chains and also regulates ubiquitin signaling through a unique, noncatalytic mechanism. OTUB1 binds to a subset of E2 ubiquitin-conjugating enzymes and inhibits their activity by trapping the E2∼ubiquitin thioester and preve...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Pasupala, Nagesh, Morrow, Marie E., Que, Lauren T., Malynn, Barbara A., Ma, Averil, Wolberger, Cynthia
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2018
Matèries:
Protein Synthesis and Degradation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6254341/
https://ncbi.nlm.nih.gov/pubmed/30282802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004677
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