Identification of binding sites for ivacaftor on the cystic fibrosis transmembrane conductance regulator

Ivacaftor (VX-770) was the first cystic fibrosis transmembrane conductance regulator (CFTR) modulatory drug approved for the treatment of patients with cystic fibrosis. Electron cryomicroscopy (cryo-EM) studies of detergent-solubilized CFTR indicated that VX-770 bound to a site at the interface betw...

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Pubblicato in:iScience
Autori principali: Laselva, Onofrio, Qureshi, Zafar, Zeng, Zhi-Wei, Petrotchenko, Evgeniy V., Ramjeesingh, Mohabir, Hamilton, C. Michael, Huan, Ling-Jun, Borchers, Christoph H., Pomès, Régis, Young, Robert, Bear, Christine E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8184517/
https://ncbi.nlm.nih.gov/pubmed/34142049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102542
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