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COVALENT INHIBITION OF BOTULINUM NEUROTOXIN A – EXPLORATION OF WARHEAD REACTIVITY AND FUNCTION USING A BIFUNCTIONAL APPROACH
INTRODUCTION AND OBJECTIVES: Botulinum neurotoxin A (BoNT/A) is extremely toxic possessing an estimated intravenous LD(50) of 1–2 ng/kg and as such has been designated a category A bioterrorism agent.(1, 2) BoNT/A also possesses an extremely long half-life and persists within muscle neurons for mont...
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| Publicado no: | Toxicon |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8183569/ https://ncbi.nlm.nih.gov/pubmed/34103769 |
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