Catch and Anchor Approach to Combat both Toxicity and Longevity of Botulinum Toxin A

Botulinum neurotoxins have remarkable persistence (~weeks to months in cells), outlasting the small molecule inhibitors designed to target them. To address this disconnect, inhibitors bearing two pharmacophores — a zinc binding group and a Cys-reactive warhead — were designed to leverage both affini...

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Pubblicato in:J Med Chem
Autori principali: Lin, Lucy, Olson, Margaret E., Sugane, Takashi, Turner, Lewis D., Tararina, Margarita A., Nielsen, Alexander L., Kurbanov, Elbek K., Pellett, Sabine, Johnson, Eric A., Cohen, Seth M., Allen, Karen N., Janda, Kim D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7581224/
https://ncbi.nlm.nih.gov/pubmed/32886509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c01006
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