Catch and Anchor Approach to Combat both Toxicity and Longevity of Botulinum Toxin A

Botulinum neurotoxins have remarkable persistence (~weeks to months in cells), outlasting the small molecule inhibitors designed to target them. To address this disconnect, inhibitors bearing two pharmacophores — a zinc binding group and a Cys-reactive warhead — were designed to leverage both affini...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Lin, Lucy, Olson, Margaret E., Sugane, Takashi, Turner, Lewis D., Tararina, Margarita A., Nielsen, Alexander L., Kurbanov, Elbek K., Pellett, Sabine, Johnson, Eric A., Cohen, Seth M., Allen, Karen N., Janda, Kim D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7581224/
https://ncbi.nlm.nih.gov/pubmed/32886509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c01006
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