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Irreversible inhibition of BoNT/A protease: proximity-driven reactivity contingent upon a bifunctional approach
Botulinum neurotoxin A (BoNT/A) is categorized as a Tier 1 bioterrorism agent and persists within muscle neurons for months, causing paralysis. A readily available treatment that abrogates BoNT/A's toxicity and longevity is a necessity in the event of a widespread BoNT/A attack and for clinical...
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| I publikationen: | RSC Med Chem |
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| Huvudupphovsmän: | , , , , , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
RSC
2021
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8221255/ https://ncbi.nlm.nih.gov/pubmed/34223161 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d1md00089f |
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