Irreversible inhibition of BoNT/A protease: proximity-driven reactivity contingent upon a bifunctional approach

Botulinum neurotoxin A (BoNT/A) is categorized as a Tier 1 bioterrorism agent and persists within muscle neurons for months, causing paralysis. A readily available treatment that abrogates BoNT/A's toxicity and longevity is a necessity in the event of a widespread BoNT/A attack and for clinical...

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Detalles Bibliográficos
Publicado en:RSC Med Chem
Main Authors: Turner, Lewis D., Nielsen, Alexander L., Lin, Lucy, Pellett, Sabine, Sugane, Takashi, Olson, Margaret E., Johnson, Eric A., Janda, Kim D.
Formato: Artigo
Idioma:Inglês
Publicado: RSC 2021
Assuntos:
Chemistry
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8221255/
https://ncbi.nlm.nih.gov/pubmed/34223161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d1md00089f
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