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Crucial mutation in the exoribonuclease domain of nsp14 of PEDV leads to high genetic instability during viral replication
BACKGROUND: Coronavirus (CoV) nonstructural protein 14 (nsp14) has exoribonuclease (ExoN) activity, responsible for proofreading and contributing to replication fidelity. It has been reported that CoVs exhibit variable sensitivity to nsp14-ExoN deficiency. Betacoronavirus murine hepatitis virus (MHV...
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| Publicado no: | Cell Biosci |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8182996/ https://ncbi.nlm.nih.gov/pubmed/34099051 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13578-021-00598-1 |
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