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“Don’t Phos Over Tau”: recent developments in clinical biomarkers and therapies targeting tau phosphorylation in Alzheimer’s disease and other tauopathies

Phosphorylation is one of the most prevalent post-translational modifications found in aggregated tau isolated from Alzheimer’s disease (AD) patient brains. In tauopathies like AD, increased phosphorylation or hyperphosphorylation can contribute to microtubule dysfunction and is associated with tau...

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Bibliografiske detaljer
Udgivet i:Mol Neurodegener
Main Authors: Xia, Yuxing, Prokop, Stefan, Giasson, Benoit I.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8180161/
https://ncbi.nlm.nih.gov/pubmed/34090488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-021-00460-5
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