Tau Ser208 phosphorylation promotes aggregation and reveals neuropathologic diversity in Alzheimer’s disease and other tauopathies

Tau protein abnormally aggregates in tauopathies, a diverse group of neurologic diseases that includes Alzheimer’s disease (AD). In early stages of disease, tau becomes hyperphosphorylated and mislocalized, which can contribute to its aggregation and toxicity. We demonstrate that tau phosphorylation...

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Vydáno v:Acta Neuropathol Commun
Hlavní autoři: Xia, Yuxing, Prokop, Stefan, Gorion, Kimberly-Marie M., Kim, Justin D., Sorrentino, Zachary A., Bell, Brach M., Manaois, Alyssa N., Chakrabarty, Paramita, Davies, Peter, Giasson, Benoit I.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2020
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7310041/
https://ncbi.nlm.nih.gov/pubmed/32571418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-00967-w
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