Tau Ser208 phosphorylation promotes aggregation and reveals neuropathologic diversity in Alzheimer’s disease and other tauopathies

Tau protein abnormally aggregates in tauopathies, a diverse group of neurologic diseases that includes Alzheimer’s disease (AD). In early stages of disease, tau becomes hyperphosphorylated and mislocalized, which can contribute to its aggregation and toxicity. We demonstrate that tau phosphorylation...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Acta Neuropathol Commun
Egile Nagusiak: Xia, Yuxing, Prokop, Stefan, Gorion, Kimberly-Marie M., Kim, Justin D., Sorrentino, Zachary A., Bell, Brach M., Manaois, Alyssa N., Chakrabarty, Paramita, Davies, Peter, Giasson, Benoit I.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2020
Gaiak:
Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7310041/
https://ncbi.nlm.nih.gov/pubmed/32571418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-00967-w
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