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Platelet Dysfunction During Mechanical Circulatory Support: Elevated Shear Stress Promotes Downregulation of α(IIb)β(3) and GPIb via Microparticle Shedding Decreasing Platelet Aggregability
OBJECTIVE. Mechanical circulatory support (MCS) has emerged as lifesaving therapy for patients with advanced heart failure. However, MCS remains limited by a paradoxical coagulopathy accompanied by both thrombosis and bleeding. While mechanisms of MCS thrombosis are increasingly defined, MCS-related...
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| Publicado en: | Arterioscler Thromb Vasc Biol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2021
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8179715/ https://ncbi.nlm.nih.gov/pubmed/33567867 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.120.315583 |
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