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Platelet Dysfunction During Mechanical Circulatory Support: Elevated Shear Stress Promotes Downregulation of α(IIb)β(3) and GPIb via Microparticle Shedding Decreasing Platelet Aggregability

OBJECTIVE. Mechanical circulatory support (MCS) has emerged as lifesaving therapy for patients with advanced heart failure. However, MCS remains limited by a paradoxical coagulopathy accompanied by both thrombosis and bleeding. While mechanisms of MCS thrombosis are increasingly defined, MCS-related...

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Bibliografiske detaljer
Udgivet i:Arterioscler Thromb Vasc Biol
Main Authors: Roka-Moiia, Yana, Miller-Gutierrez, Samuel, Palomares, Daniel E., Italiano, Joseph E., Sheriff, Jawaad, Bluestein, Danny, Slepian, Marvin J.
Format: Artigo
Sprog:Inglês
Udgivet: 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8179715/
https://ncbi.nlm.nih.gov/pubmed/33567867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.120.315583
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