Computational strategy for intrinsically disordered protein ligand design leads to the discovery of p53 transactivation domain I binding compounds that activate the p53 pathway

Intrinsically disordered proteins or intrinsically disordered regions (IDPs) have gained much attention in recent years due to their vital roles in biology and prevalence in various human diseases. Although IDPs are perceived as attractive therapeutic targets, rational drug design targeting IDPs rem...

Full description

Saved in:
Bibliographic Details
Published in:Chem Sci
Main Authors: Ruan, Hao, Yu, Chen, Niu, Xiaogang, Zhang, Weilin, Liu, Hanzhong, Chen, Limin, Xiong, Ruoyao, Sun, Qi, Jin, Changwen, Liu, Ying, Lai, Luhua
Format: Artigo
Language:Inglês
Published: The Royal Society of Chemistry 2020
Subjects:
Chemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8179352/
https://ncbi.nlm.nih.gov/pubmed/34164069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc04670a
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items