Computational strategy for intrinsically disordered protein ligand design leads to the discovery of p53 transactivation domain I binding compounds that activate the p53 pathway

Intrinsically disordered proteins or intrinsically disordered regions (IDPs) have gained much attention in recent years due to their vital roles in biology and prevalence in various human diseases. Although IDPs are perceived as attractive therapeutic targets, rational drug design targeting IDPs rem...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Chem Sci
Prif Awduron: Ruan, Hao, Yu, Chen, Niu, Xiaogang, Zhang, Weilin, Liu, Hanzhong, Chen, Limin, Xiong, Ruoyao, Sun, Qi, Jin, Changwen, Liu, Ying, Lai, Luhua
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Royal Society of Chemistry 2020
Pynciau:
Chemistry
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8179352/
https://ncbi.nlm.nih.gov/pubmed/34164069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc04670a
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