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Structure-based Inhibitor Design for the Intrinsically Disordered Protein c-Myc
Intrinsically disordered proteins (IDPs) are associated with various diseases and have been proposed as promising drug targets. However, conventional structure-based approaches cannot be applied directly to IDPs, due to their lack of ordered structures. Here, we describe a novel computational approa...
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| Udgivet i: | Sci Rep |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4773988/ https://ncbi.nlm.nih.gov/pubmed/26931396 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22298 |
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