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Structure-based Inhibitor Design for the Intrinsically Disordered Protein c-Myc

Intrinsically disordered proteins (IDPs) are associated with various diseases and have been proposed as promising drug targets. However, conventional structure-based approaches cannot be applied directly to IDPs, due to their lack of ordered structures. Here, we describe a novel computational approa...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Yu, Chen, Niu, Xiaogang, Jin, Fan, Liu, Zhirong, Jin, Changwen, Lai, Luhua
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4773988/
https://ncbi.nlm.nih.gov/pubmed/26931396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22298
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