Prespacers formed during primed adaptation associate with the Cas1–Cas2 adaptation complex and the Cas3 interference nuclease–helicase

For Type I CRISPR-Cas systems, a mode of CRISPR adaptation named priming has been described. Priming allows specific and highly efficient acquisition of new spacers from DNA recognized (primed) by the Cascade-crRNA (CRISPR RNA) effector complex. Recognition of the priming protospacer by Cascade-crRN...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Musharova, Olga, Medvedeva, Sofia, Klimuk, Evgeny, Guzman, Noemi Marco, Titova, Daria, Zgoda, Victor, Shiriaeva, Anna, Semenova, Ekaterina, Severinov, Konstantin, Savitskaya, Ekaterina
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2021
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8179228/
https://ncbi.nlm.nih.gov/pubmed/34035168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2021291118
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