Spacer-length DNA intermediates are associated with Cas1 in cells undergoing primed CRISPR adaptation

During primed CRISPR adaptation spacers are preferentially selected from DNA recognized by CRISPR interference machinery, which in the case of Type I CRISPR–Cas systems consists of CRISPR RNA (crRNA) bound effector Cascade complex that locates complementary targets, and Cas3 executor nuclease/helica...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Main Authors: Musharova, Olga, Klimuk, Evgeny, Datsenko, Kirill A., Metlitskaya, Anastasia, Logacheva, Maria, Semenova, Ekaterina, Severinov, Konstantin, Savitskaya, Ekaterina
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2017
Assuntos:
Molecular Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389516/
https://ncbi.nlm.nih.gov/pubmed/28204574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx097
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