Detection of spacer precursors formed in vivo during primed CRISPR adaptation

Type I CRISPR-Cas loci provide prokaryotes with a nucleic-acid-based adaptive immunity against foreign DNA. Immunity involves adaptation, the integration of ~30-bp DNA fragments, termed prespacers, into the CRISPR array as spacers, and interference, the targeted degradation of DNA containing a proto...

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Publicado en:Nat Commun
Main Authors: Shiriaeva, Anna A., Savitskaya, Ekaterina, Datsenko, Kirill A., Vvedenskaya, Irina O., Fedorova, Iana, Morozova, Natalia, Metlitskaya, Anastasia, Sabantsev, Anton, Nickels, Bryce E., Severinov, Konstantin, Semenova, Ekaterina
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6787059/
https://ncbi.nlm.nih.gov/pubmed/31601800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12417-w
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