Avoidance of Trinucleotide Corresponding to Consensus Protospacer Adjacent Motif Controls the Efficiency of Prespacer Selection during Primed Adaptation

CRISPR DNA arrays of unique spacers separated by identical repeats ensure prokaryotic immunity through specific targeting of foreign nucleic acids complementary to spacers. New spacers are acquired into a CRISPR array in a process of CRISPR adaptation. Selection of foreign DNA fragments to be integr...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Musharova, Olga, Vyhovskyi, Danylo, Medvedeva, Sofia, Guzina, Jelena, Zhitnyuk, Yulia, Djordjevic, Marko, Severinov, Konstantin, Savitskaya, Ekaterina
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6282206/
https://ncbi.nlm.nih.gov/pubmed/30514784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02169-18
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