Epigenetic and post-transcriptional modulation of SOS1 can promote breast cancer metastasis through obesity-activated c-Met signaling in African American women

Ethnicity is considered to be one of the major risk factors in certain subtypes of breast cancer. However, the mechanism of this racial disparity remains poorly understood. Here we demonstrate that SOS1, a key regulator of Ras pathway, is highly expressed in African American (AA) breast cancer patie...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Xing, Fei, Zhao, Dan, Wu, Shih‐Ying, Tyagi, Abhishek, Wu, Kerui, Sharma, Sambad, Liu, Yin, Deshpande, Ravindra, Wang, Yuezhu, Cleary, Jacob, Miller, Lance D., Chittiboyina, Amar G., Yalamanchili, Chinni, Mo, Yin-Yuan, Watabe, Kounosuke
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8178187/
https://ncbi.nlm.nih.gov/pubmed/33446575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-4031
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