Epigenetic and post-transcriptional modulation of SOS1 can promote breast cancer metastasis through obesity-activated c-Met signaling in African American women

Ethnicity is considered to be one of the major risk factors in certain subtypes of breast cancer. However, the mechanism of this racial disparity remains poorly understood. Here we demonstrate that SOS1, a key regulator of Ras pathway, is highly expressed in African American (AA) breast cancer patie...

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Gepubliceerd in:Cancer Res
Hoofdauteurs: Xing, Fei, Zhao, Dan, Wu, Shih‐Ying, Tyagi, Abhishek, Wu, Kerui, Sharma, Sambad, Liu, Yin, Deshpande, Ravindra, Wang, Yuezhu, Cleary, Jacob, Miller, Lance D., Chittiboyina, Amar G., Yalamanchili, Chinni, Mo, Yin-Yuan, Watabe, Kounosuke
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2021
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8178187/
https://ncbi.nlm.nih.gov/pubmed/33446575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-4031
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