Nicotine promotes brain metastasis by polarizing microglia and suppressing innate immune function

Up to 40% of lung cancer patients develop brain metastasis, and the median survival of these patients remains less than 6 months. Smoking is associated with lung cancer. However, how smoking impacts the development of brain metastasis remains elusive. We examined 281 lung cancer patients with distan...

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Udgivet i:J Exp Med
Main Authors: Wu, Shih-Ying, Xing, Fei, Sharma, Sambad, Wu, Kerui, Tyagi, Abhishek, Liu, Yin, Zhao, Dan, Deshpande, Ravindra Pramod, Shiozawa, Yusuke, Ahmed, Tamjeed, Zhang, Wei, Chan, Michael, Ruiz, Jimmy, Lycan, Thomas W., Dothard, Andrew, Watabe, Kounosuke
Format: Artigo
Sprog:Inglês
Udgivet: Rockefeller University Press 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7398164/
https://ncbi.nlm.nih.gov/pubmed/32496556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20191131
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