Mimicking SIV chimpanzee viral evolution towards HIV-1 during cross-species transmission

HIV-1 evolved from SIV during cross-species transmission events, though viral genetic changes are not well understood. Here we studied the evolution of SIVcpzLB715 into HIV-1 Group M using humanized mice. High viral loads, rapid CD4(+) T-cell decline, and non-synonymous substitutions were identified...

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Pubblicato in:J Med Primatol
Autori principali: Schmitt, Kimberly, Curlin, James, Remling-Mulder, Leila, Moriarty, Ryan, Goff, Kelly, O’Connor, Shelby, Stenglein, Mark, Marx, Preston, Akkina, Ramesh
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8177655/
https://ncbi.nlm.nih.gov/pubmed/33460210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jmp.12485
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