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SIV progenitor evolution towards HIV: A humanized mouse surrogate model for SIVsm adaptation towards HIV-2
How SIV progenitors evolved into deadly HIV-1 and HIV-2 following initial cross-species transmission still remains a mystery. Here we used humanized mice as a human surrogate system to evaluate SIVsm evolution into HIV-2. Increased viral virulence to human CD4(+) T cells and adaptive genetic changes...
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| Publicado no: | J Med Primatol |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6464631/ https://ncbi.nlm.nih.gov/pubmed/30255956 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jmp.12380 |
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