Cross-Species Transmission and Evolution of SIV Chimpanzee Progenitor Viruses Toward HIV-1 in Humanized Mice

The genetic evolution of HIV-1 from its progenitor virus SIV following cross-species transmission is not well understood. Here we simulated the SIVcpz initial transmission to humans using humanized mice and followed the viral evolution during serial passages lasting more than a year. All three SIVcp...

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Detalhes bibliográficos
Publicado no:Front Microbiol
Main Authors: Schmitt, Kimberly, Curlin, James, Remling-Mulder, Leila, Moriarty, Ryan, Goff, Kelly, O’Connor, Shelby, Stenglein, Mark, Marx, Preston, Akkina, Ramesh
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7432304/
https://ncbi.nlm.nih.gov/pubmed/32849468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2020.01889
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