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Modeling the evolution of SIV sooty mangabey progenitor virus towards HIV-2 using humanized mice

HIV-2 is thought to have originated from an SIV progenitor native to sooty mangabeys. To model the initial human transmission and understand the sequential viral evolution, humanized mice were infected with SIVsm and serially passaged for five generations. Productive infection was seen by week 3 dur...

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Detalhes bibliográficos
Publicado no:Virology
Main Authors: Schmitt, Kimberly, Kumar, Dipu Mohan, Curlin, James, Remling-Mulder, Leila, Stenglein, Mark, O’Connor, Shelby, Marx, Preston, Akkina, Ramesh
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5906053/
https://ncbi.nlm.nih.gov/pubmed/28750321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2017.07.005
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