How oncogenic mutations activate human MAP kinase 1 (MEK1): A molecular dynamics simulation study

Approximately 30% of all types of human cancers possess a constitutively activated the mitogen-activated protein kinase (MAPK) signaling pathway while MAP kinase 1 (MEK1) is a critical component of this pathway. It has been reported mutations could improve the activity of MEK1 to result in cell prol...

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Udgivet i:J Biomol Struct Dyn
Main Authors: Liu, Ye, Zhu, Jingxuan, Guo, Xiaoqing, Huang, Tianci, Han, Jiarui, Gao, Jianjiong, Xu, Dong, Han, Weiwei
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8177546/
https://ncbi.nlm.nih.gov/pubmed/31658877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/07391102.2019.1686065
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