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How oncogenic mutations activate human MAP kinase 1 (MEK1): A molecular dynamics simulation study
Approximately 30% of all types of human cancers possess a constitutively activated the mitogen-activated protein kinase (MAPK) signaling pathway while MAP kinase 1 (MEK1) is a critical component of this pathway. It has been reported mutations could improve the activity of MEK1 to result in cell prol...
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| Publicado en: | J Biomol Struct Dyn |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8177546/ https://ncbi.nlm.nih.gov/pubmed/31658877 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/07391102.2019.1686065 |
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