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Computational Study on the Effect of Inactivating/Activating Mutations on the Inhibition of MEK1 by Trametinib
Activation of the mitogen-activated protein kinase (MAPK) signaling pathway regulated by human MAP kinase 1 (MEK1) is associated with the carcinogenesis and progression of numerous cancers. In addition, two active mutations (P124S and E203K) have been reported to enhance the activity of MEK1, thereb...
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| Опубликовано в: : | Int J Mol Sci |
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| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
MDPI
2020
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7139317/ https://ncbi.nlm.nih.gov/pubmed/32245216 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21062167 |
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