How activating mutations affect MEK1 regulation and function

The MEK1 kinase directly phosphorylates ERK2, after the activation loop of MEK1 is itself phosphorylated by Raf. Studies over the past decade have revealed a large number of disease-related mutations in the MEK1 gene that lead to tumorigenesis and abnormal development. Several of these mutations res...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Jindal, Granton A., Goyal, Yogesh, Humphreys, John M., Yeung, Eyan, Tian, Kaijia, Patterson, Victoria L., He, Haixia, Burdine, Rebecca D., Goldsmith, Elizabeth J., Shvartsman, Stanislav Y.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2017
Soggetti:
Accelerated Communications
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5704466/
https://ncbi.nlm.nih.gov/pubmed/29018093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C117.806067
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