How activating mutations affect MEK1 regulation and function

The MEK1 kinase directly phosphorylates ERK2, after the activation loop of MEK1 is itself phosphorylated by Raf. Studies over the past decade have revealed a large number of disease-related mutations in the MEK1 gene that lead to tumorigenesis and abnormal development. Several of these mutations res...

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Vydáno v:J Biol Chem
Hlavní autoři: Jindal, Granton A., Goyal, Yogesh, Humphreys, John M., Yeung, Eyan, Tian, Kaijia, Patterson, Victoria L., He, Haixia, Burdine, Rebecca D., Goldsmith, Elizabeth J., Shvartsman, Stanislav Y.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2017
Témata:
Accelerated Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5704466/
https://ncbi.nlm.nih.gov/pubmed/29018093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C117.806067
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