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Connecting Rodent and Human Pharmacokinetic Models for the Design and Translation of Glucose-Responsive Insulin

Despite considerable progress, development of glucose-responsive insulins (GRIs) still largely depends on empirical knowledge and tedious experimentation—especially on rodents. To assist the rational design and clinical translation of the therapeutic, we present a Pharmacokinetic Algorithm Mapping G...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Yang, Jing Fan, Gong, Xun, Bakh, Naveed A., Carr, Kelley, Phillips, Nelson F.B., Ismail-Beigi, Faramarz, Weiss, Michael A., Strano, Michael S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8176262/
https://ncbi.nlm.nih.gov/pubmed/32152206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db19-0879
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