Solution structure of an ultra-stable single-chain insulin analog connects protein dynamics to a novel mechanism of receptor binding

Por Glidden, Michael D., Yang, Yanwu, Smith, Nicholas A., Phillips, Nelson B., Carr, Kelley, Wickramasinghe, Nalinda P., Ismail-Beigi, Faramarz, Lawrence, Michael C., Smith, Brian J., Weiss, Michael A.
Publicado no J Biol Chem (2018)

An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein

Por Glidden, Michael D., Aldabbagh, Khadijah, Phillips, Nelson B., Carr, Kelley, Chen, Yen-Shan, Whittaker, Jonathan, Phillips, Manijeh, Wickramasinghe, Nalinda P., Rege, Nischay, Swain, Mamuni, Peng, Yi, Yang, Yanwu, Lawrence, Michael C., Yee, Vivien C., Ismail-Beigi, Faramarz, Weiss, Michael A.
Publicado no J Biol Chem (2018)