4-Hydroxy-2-nonenal antimicrobial toxicity is neutralized by an intracellular pathogen

Pathogens encounter numerous antimicrobial responses during infection, including the reactive oxygen species (ROS) burst. ROS-mediated oxidation of host membrane poly-unsaturated fatty acids (PUFAs) generates the toxic alpha-beta carbonyl 4-hydroxy-2-nonenal (4-HNE). Although studied extensively in...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Tabakh, Hannah, McFarland, Adelle P, Thomason, Maureen K, Pollock, Alex J, Glover, Rochelle C, Zaver, Shivam A, Woodward, Joshua J
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2021
Assuntos:
Microbiology and Infectious Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8174450/
https://ncbi.nlm.nih.gov/pubmed/33955352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.59295
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