Inhibition of Aminoacylase 3 Protects Rat Brain Cortex Neuronal Cells from the Toxicity of 4-Hydroxy-2-nonenal Mercapturate and 4-Hydroxy-2-nonenal

4-Hydroxy-2-nonenal (HNE) and acrolein are highly reactive neurotoxic products of lipid peroxidation that accumulate in Alzheimer’s and Parkinson’s disease brain and are implicated in the pathogenesis and progression of these neurological diseases. Conjugation with glutathione (GSH) initiates the HN...

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Publicat a:Toxicol Appl Pharmacol
Autors principals: Tsirulnikov, Kirill, Abuladze, Natalia, Bragin, Anatol, Faull, Kym, Cascio, Duilio, Damoiseaux, Robert, Schibler, Matthew J., Pushkin, Alexander
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5575769/
https://ncbi.nlm.nih.gov/pubmed/22819785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2012.07.002
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