Inhibition of Aminoacylase 3 Protects Rat Brain Cortex Neuronal Cells from the Toxicity of 4-Hydroxy-2-nonenal Mercapturate and 4-Hydroxy-2-nonenal

4-Hydroxy-2-nonenal (HNE) and acrolein are highly reactive neurotoxic products of lipid peroxidation that accumulate in Alzheimer’s and Parkinson’s disease brain and are implicated in the pathogenesis and progression of these neurological diseases. Conjugation with glutathione (GSH) initiates the HN...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Toxicol Appl Pharmacol
Prif Awduron: Tsirulnikov, Kirill, Abuladze, Natalia, Bragin, Anatol, Faull, Kym, Cascio, Duilio, Damoiseaux, Robert, Schibler, Matthew J., Pushkin, Alexander
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2012
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5575769/
https://ncbi.nlm.nih.gov/pubmed/22819785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2012.07.002
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