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Inhibition of Aminoacylase 3 Protects Rat Brain Cortex Neuronal Cells from the Toxicity of 4-Hydroxy-2-nonenal Mercapturate and 4-Hydroxy-2-nonenal

4-Hydroxy-2-nonenal (HNE) and acrolein are highly reactive neurotoxic products of lipid peroxidation that accumulate in Alzheimer’s and Parkinson’s disease brain and are implicated in the pathogenesis and progression of these neurological diseases. Conjugation with glutathione (GSH) initiates the HN...

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Detalhes bibliográficos
Publicado no:Toxicol Appl Pharmacol
Main Authors: Tsirulnikov, Kirill, Abuladze, Natalia, Bragin, Anatol, Faull, Kym, Cascio, Duilio, Damoiseaux, Robert, Schibler, Matthew J., Pushkin, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5575769/
https://ncbi.nlm.nih.gov/pubmed/22819785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2012.07.002
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