Inhibition of Aminoacylase 3 Protects Rat Brain Cortex Neuronal Cells from the Toxicity of 4-Hydroxy-2-nonenal Mercapturate and 4-Hydroxy-2-nonenal

4-Hydroxy-2-nonenal (HNE) and acrolein are highly reactive neurotoxic products of lipid peroxidation that accumulate in Alzheimer’s and Parkinson’s disease brain and are implicated in the pathogenesis and progression of these neurological diseases. Conjugation with glutathione (GSH) initiates the HN...

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Gepubliceerd in:Toxicol Appl Pharmacol
Hoofdauteurs: Tsirulnikov, Kirill, Abuladze, Natalia, Bragin, Anatol, Faull, Kym, Cascio, Duilio, Damoiseaux, Robert, Schibler, Matthew J., Pushkin, Alexander
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2012
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5575769/
https://ncbi.nlm.nih.gov/pubmed/22819785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2012.07.002
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