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Dynamic Analysis of 4E-BP1 Phosphorylation in Neurons with Tsc2 or Depdc5 Knockout
TSC1 or TSC2 mutations cause Tuberous Sclerosis Complex (TSC), and lead to mechanistic target of rapamycin (mTOR) hyperactivation evidenced by hyperphosphorylation of ribosomal S6 protein and 4-elongation factor binding protein (4E-BP1). Amino acid (AA) levels modulate mTOR-dependent S6 and 4E-BP1 p...
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| Publicado no: | Exp Neurol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8170708/ https://ncbi.nlm.nih.gov/pubmed/32781001 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2020.113432 |
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