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DEPDC5 and NPRL3 Modulate Cell Size, Filopodial Outgrowth, and Localization of mTOR in Neural Progenitor Cells and Neurons
Mutations in DEPDC5 and NPRL3 subunits of GATOR1, a modulator of mechanistic target of rapamycin (mTOR), are linked to malformations of cortical development (MCD). Brain specimens from these individuals reveal abnormal cortical lamination, altered cell morphology, and hyperphosphorylation of ribosom...
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| Publicado en: | Neurobiol Dis |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6413529/ https://ncbi.nlm.nih.gov/pubmed/29481864 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2018.02.013 |
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