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DEPDC5 and NPRL3 Modulate Cell Size, Filopodial Outgrowth, and Localization of mTOR in Neural Progenitor Cells and Neurons

Mutations in DEPDC5 and NPRL3 subunits of GATOR1, a modulator of mechanistic target of rapamycin (mTOR), are linked to malformations of cortical development (MCD). Brain specimens from these individuals reveal abnormal cortical lamination, altered cell morphology, and hyperphosphorylation of ribosom...

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Detalhes bibliográficos
Publicado no:Neurobiol Dis
Main Authors: Iffland, Philip H., Baybis, Marianna, Barnes, Allan E., Leventer, Richard J., Lockhart, Paul J., Crino, Peter B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6413529/
https://ncbi.nlm.nih.gov/pubmed/29481864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2018.02.013
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