Differential Reponses of Hematopoietic Stem and Progenitor Cells to mTOR Inhibition

Abnormal activation of the mammalian target of rapamycin (mTOR) signaling pathway has been observed in a variety of human cancers. Therefore, targeting of the mTOR pathway is an attractive strategy for cancer treatment and several mTOR inhibitors, including AZD8055 (AZD), a novel dual mTORC1/2 inhib...

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Veröffentlicht in:Stem Cells Int
Hauptverfasser: Yang, Aimin, Xiao, Xia, Zhao, Mingfeng, LaRue, Amanda C., Schulte, Bradley A., Wang, Gavin Y.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi Publishing Corporation 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4499403/
https://ncbi.nlm.nih.gov/pubmed/26221145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/561404
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