A Mouse Model of DEPDC5-related Epilepsy: Neuronal Loss of Depdc5 Causes Dysplastic and Ectopic Neurons, Increased mTOR Signaling, and Seizure Susceptibility

DEPDC5 is a newly identified epilepsy-related gene implicated in focal epilepsy, brain malformations, and Sudden Unexplained Death in Epilepsy (SUDEP). In vitro, DEPDC5 negatively regulates amino acid sensing by the mTOR complex 1 (mTORC1) pathway, but the role of DEPDC5 in neurodevelopment and epil...

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Publicado en:Neurobiol Dis
Main Authors: Yuskaitis, Christopher J., Jones, Brandon M., Wolfson, Rachel L., Super, Chloe E., Dhamne, Sameer C., Rotenberg, Alexander, Sabatini, David M., Sahin, Mustafa, Poduri, Annapurna
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5803417/
https://ncbi.nlm.nih.gov/pubmed/29274432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2017.12.010
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