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4E-BP restrains eIF4E phosphorylation
In eukaryotes, mRNA translation is dependent on the cap-binding protein eIF4E. Through its simultaneous interaction with the mRNA cap structure and with the ribosome-associated eIF4G adaptor protein, eIF4E physically posits the ribosome at the 5′ extremity of capped mRNA. eIF4E activity is regulated...
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| Gepubliceerd in: | Translation (Austin) |
|---|---|
| Hoofdauteurs: | , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Taylor & Francis
2013
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4718053/ https://ncbi.nlm.nih.gov/pubmed/26824022 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/trla.25819 |
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