eIF4A inhibition circumvents uncontrolled DNA replication mediated by 4E-BP1 loss in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) relies on hyperactivated protein synthesis. Consistently, human and mouse PDAC lose expression of the translational repressor and mTOR target 4E-BP1. Using genome-wide polysome profiling, we here explore mRNAs whose translational efficiencies depend on the mTO...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Müller, David, Shin, Sauyeun, Goullet de Rugy, Théo, Samain, Rémi, Baer, Romain, Strehaiano, Manon, Masvidal-Sanz, Laia, Guillermet-Guibert, Julie, Jean, Christine, Tsukumo, Yoshinori, Sonenberg, Nahum, Marion, Frédéric, Guilbaud, Nicolas, Hoffmann, Jean-Sébastien, Larsson, Ola, Bousquet, Corinne, Pyronnet, Stéphane, Martineau, Yvan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6948775/
https://ncbi.nlm.nih.gov/pubmed/31672935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.121951
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