EMBR-01. CLASS I HDAC INHIBITORS AND PLK1 INHIBITORS SYNERGIZE IN MYC-AMPLIFIED MEDULLOBLASTOMA

BACKGROUND: Medulloblastoma (MB) is one of the most common malignant pediatric CNS tumors. Patients with Group 3 MBs harboring MYC amplification exhibit low survival rates. Surviving patients suffer from therapy-induced sequelae, which calls for new targeted therapy strategies. We and others have pr...

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Опубликовано в: :Neuro Oncol
Главные авторы: Valinciute, Gintvile, Ecker, Jonas, Selt, Florian, Hielscher, Thomas, Schmidt, Christin, Sigaud, Romain, Ridinger, Johannes, Gatzweiler, Charlotte, Picard, Daniel, Oppermann, Sina, Blattner-Johnson, Mirjam, Jones, David T W, Oehme, Ina, Kool, Marcel, Remke, Marc, Pfister, Stefan M, Witt, Olaf, Milde, Till
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2021
Предметы:
Embryonal Tumors
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8168241/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noab090.019
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