LGG-09. SENOLYTIC AGENT NAVITOCLAX TARGETS VINBLASTINE- AND MAPK INHIBITORS-INDUCED SENESCENT TUMOUR CELLS IN PAEDIATRIC LOW GRADE GLIOMAS

Pilocytic astrocytoma (PA, WHO grade I), the most common paediatric brain tumour, is characterized by constitutive activation of the MAPK pathway. PA tumours show a slow growth, without tendency to progress to high-grade malignancies. However, a significant group of patients for whom a total resecti...

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Udgivet i:Neuro Oncol
Main Authors: Guiho, Romain, Selt, Florian, Stone, Thomas, Jacques, Thomas, Hargrave, Darren, Gil, Jesús, Witt, Olaf, Milde, Till, Barbera, Juan Pedro Martinez
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2021
Fag:
Low Grade Gliomas
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8168216/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noab090.133
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