Lysosome and Inflammatory Defects in GBA1-Mutant Astrocytes Are Normalized by LRRK2 Inhibition

BACKGROUND: Autosomal recessive mutations in the glucocerebrosidase gene, Beta-glucocerebrosidase 1 (GBA1), cause the lysosomal storage disorder Gaucher’s disease. Heterozygous carriers of most GBA1 mutations have dramatically increased Parkinson’s disease (PD) risk, but the mechanisms and cells aff...

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Xehetasun bibliografikoak
Argitaratua izan da:Mov Disord
Egile Nagusiak: Sanyal, Anwesha, DeAndrade, Mark P., Novis, Hailey S., Lin, Steven, Chang, Jianjun, Lengacher, Nathalie, Tomlinson, Julianna J., Tansey, Malú G., LaVoie, Matthew J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2020
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8167931/
https://ncbi.nlm.nih.gov/pubmed/32034799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mds.27994
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