Upregulation of endogenous TRAIL-elicited apoptosis is essential for metformin-mediated antitumor activity against TNBC and NSCLC

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) shows promising antitumor activity in preclinical studies. However, the efficacy of recombinant TRAIL in clinical trials is compromised by its short serum half-life and low in vivo stability. Induction of endogenous TRAIL may overcome t...

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Dettagli Bibliografici
Pubblicato in:Mol Ther Oncolytics
Autori principali: Liu, Shuang, Polsdofer, Erik V., Zhou, Lukun, Ruan, Sanbao, Lyu, Hui, Hou, Defu, Liu, Hao, Thor, Ann D., He, Zhimin, Liu, Bolin
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Gene & Cell Therapy 2021
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8167201/
https://ncbi.nlm.nih.gov/pubmed/34141868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omto.2021.04.012
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